Research Scientist for Long-term Organoid Expansion and R&D (Oncology) | BomaLink

Research Scientist for Long-term Organoid Expansion and R&D (Oncology)

Biotechnology Research

Posted 1 year ago

Details

Title: Research Scientist

SEngine Precision Medicine Inc. is a precision oncology company revolutionizing cancer diagnostics and therapies by pre-testing drugs on organoids derived from patient tumor cells. A spin-out from the world-renowned Fred Hutchinson Cancer Research Center, SEngine is leveraging over two decades of R&D in diagnostics and drug discovery. The company is commercializing the PARIS® Test, a next generation diagnostic test that predicts drug responses integrating knowledge of cancer genomics with organoids, robotics, and computational tools. SEngine’s CLIA certified PARIS® Test generates predictive drug sensitivity reports for patients with solid tumors. SEngine is also pursuing drug discovery via strategic collaborations with pharmaceutical companies and by leveraging its precision oncology platform.

Our environment is rigorous, fast-paced and collaborative, bringing together passionate individuals who are making an impact. We inspire creativity and discovery by embracing an open culture that fosters innovation, teamwork, and excellence.

SEngine Precision Medicine, is seeking a highly skilled and motivated Research Scientist to support our CLIA laboratory and Drug Discovery teams. The ideal candidate will have a strong background in aseptic mammalian cell culture, ideally 3-D primary cell culture with experience in cell and molecular biology. A passion for utilizing 3-D culture models to understand the biology of cancer with the goal of providing novel therapeutics for patients. The candidate will be asked to troubleshoot, think out of the box, keep up with the cutting-edge organoid literature to implement the long-term expansion for multiple cancer PDO (Patient Derived Organoids) types.

This position reports directly to the Associate Director of the Organoid Laboratory, but the candidate will work closely with the Drug Discovery team as well.

Required Qualifications will include but are not limited to:
  • Master’s or PhD in biology or relevant field.
  • Minimum of 2 years’ experience in growing 2D cancer cell lines and minimum of one year experience in 3D cancer organoids expansion, in BSL2 laboratory.
  • Maintain detailed laboratory and electronic records demonstrating adherence to SOPs.
  • Support in planning and executing cell-based assays and molecular biology/biochemistry experiments (DNA, RNA, Protein) using 2-D and 3-D cell culture samples
  • Analyze, interpret, and effectively communicate results to supervisor and team members
  • Effectively communicate with both organoid core and drug discovery teams to execute experiments
  • Independent achiever but also capable of working in teams.
  • Familiarity with cell viability assays and other cell-based assays.
  • Professional working proficiency in Microsoft Office.

Desired Qualifications:
  • Leading or co-authorship publications related to the culture and characterization of PDTO (Patient -Derived-Tumor Organoids)
  • Contributed to meeting Abstracts or Presentations in PDTOs
  • Experience in utilizing laboratory automation, enabling high throughput cell-based assays, such as automated cell-plating devices, experience in manual and automated cell counters, and experience with benchtop semi-automated tissue dissociation instrument.
  • 1+ years clinical laboratory experience.
  • Experience with immunofluorescence and immunohistochemistry staining.

Job Type: Full-time, FLSA status: Exempt, Location: Seattle, WA

Join us! SEngine Precision Medicine offers a competitive compensation and benefits package. Please apply with a short cover letter and resume. You are also welcome to call 206-788-5083 for questions.

Visit us: https://senginemedicine.com

SEngine Precision Medicine is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, gender, religion, national origin, disability, and veteran status.

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